edu.ucar.opensky::articles:26745 UCAR/NCAR - Library OpenSky Support PO Box 3000 Boulder CO 80307-3000 opensky@ucar.edu http://opensky.ucar.edu/ homepage pointOfContact 2025-12-24T19:55:55.376524 ISO 19115-2 Geographic Information - Metadata - Part 2: Extensions for Imagery and Gridded Data ISO 19115-2:2009(E) https://n2t.org/ark:/85065/d78w3jc8 https://doi.org/10.7924/r4d223179 https Related Dataset #1 Data from: Automated design of 3D DNA origami with non-rasterized 2D curvature Automated design of 3D DNA origami with non-rasterized 2D curvature 2022-12-23T00:00:00Z publication https://n2t.org/ark:/85065/d78w3jc8 https://doi.org/10.1126/sciadv.ade4455 Fu, D. author Pradeep Narayanan, R. author Prasad, A. author Zhang, F. author Williams, D. author Schreck, John S. author Yan, H. author Reif, J. author UCAR/NCAR - Library publisher Improving the precision and function of encapsulating three-dimensional (3D) DNA nanostructures via curved geometries could have transformative impacts on areas such as molecular transport, drug delivery, and nanofabrication. However, the addition of non-rasterized curvature escalates design complexity without algorithmic regularity, and these challenges have limited the ad hoc development and usage of previously unknown shapes. In this work, we develop and automate the application of a set of previously unknown design principles that now includes a multilayer design for closed and curved DNA nanostructures to resolve past obstacles in shape selection, yield, mechanical rigidity, and accessibility. We design, analyze, and experimentally demonstrate a set of diverse 3D curved nanoarchitectures, showing planar asymmetry and examining partial multilayer designs. Our automated design tool implements a combined algorithmic and numerical approximation strategy for scaffold routing and crossover placement, which may enable wider applications of general DNA nanostructure design for nonregular or oblique shapes. UCAR/NCAR - Library OpenSky Support PO Box 3000 Boulder CO 80307-3000 opensky@ucar.edu http://opensky.ucar.edu/ homepage pointOfContact PDF Text theme Resource Type 2016-01-01T00:00:00Z publication Copyright author(s). This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. None eng geoscientificInformation